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Within this framework, we critically examine representative nanotherapeutic strategies across pharmacokinetic and biodistribution-oriented design, vascular and stromal normalization, tumor microenvironment-responsive activation, immune priming and intratumoral reprogramming, and clinically relevant theranostic approaches

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TB-500 operates primarily through actin polymerization and cell migration signaling, without the angiogenic mechanism that defines research into this compound

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